The molecular basis of behavioural acid insensitivity in the African naked mole-rat
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چکیده
منابع مشابه
Selective Inflammatory Pain Insensitivity in the African Naked Mole-Rat (Heterocephalus glaber)
In all mammals, tissue inflammation leads to pain and behavioral sensitization to thermal and mechanical stimuli called hyperalgesia. We studied pain mechanisms in the African naked mole-rat, an unusual rodent species that lacks pain-related neuropeptides (e.g., substance P) in cutaneous sensory fibers. Naked mole-rats show a unique and remarkable lack of pain-related behaviors to two potent al...
متن کاملNaked mole-rat
It’s a mammal Jim, but not as we know it... Mammals are typically characterised as furry and warmblooded. The naked mole-rat is neither of these. Being underground and surrounded by hundreds of brothers and sisters, there is little fluctuation in surrounding temperature and they have all but lost the ability to regulate their body temperature physiologically. Living in the dark, they can no lon...
متن کاملHypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat
The naked mole-rat is a subterranean rodent lacking several pain behaviors found in humans, rats, and mice. For example, nerve growth factor (NGF), an important mediator of pain sensitization, fails to produce thermal hyperalgesia in naked mole-rats. The sensitization of capsaicin-sensitive TRPV1 ion channels is necessary for NGF-induced hyperalgesia, but naked mole-rats have fully functional T...
متن کاملBehavioural ecology: Naked mole-rats on the move
In the 1970s, R.D. Alexander attempted to explain the apparent absence of eusociality in vertebrates by describing a mythical creature with all the traits needed for eusociality: probably a rodent, it would live a cooperative existence constructing an expandable nest in a safe subterranean environment, exploiting a large, almost risk-free food source [1]. Unknown to Alexander at the time, he ha...
متن کاملAbsence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P
Recent research has proposed a pathway in which sensory neurons expressing the capsaicin activated ion channel TRPV1 are required for histamine-induced itch and subsequent scratching behavior. We examined histamine-induced itch in the African naked mole-rat (Heterocephalus glaber) and found that although naked mole-rats display innate scratching behavior, histamine was unable to evoke increased...
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ژورنال
عنوان ژورنال: Frontiers in Behavioral Neuroscience
سال: 2012
ISSN: 1662-5153
DOI: 10.3389/conf.fnbeh.2012.27.00009